Usefulness of Gly m 4‐specific <scp>IgE</scp> test in the diagnosis of Rosaceae fruit‐oral allergy syndrome caused by Betulaceae pollen sensitization

Abstract Background Pollen‐food allergy syndrome (PFAS) is caused by the cross‐reaction of specific IgE to pollen allergens with similar contained in fruits, vegetable, and nuts. The representative allergen responsible for this pathogenesis‐related protein (PR)‐10. Specific test using Gly m 4, soybean PR‐10, widely used diagnose soy allergy. We aimed investigate whether 4‐specific useful predicting oral symptoms (OAS) Rosaceae fruits PFAS Betulaceae sensitization. Methods Forty‐one patients suspected were enrolled. levels measured against alder pollen, apple, peach, pear, correlation between results allergic was assessed compare accuracy these allergen‐specific tests. Results Of 41 patients, 32 positive pollen‐specific IgE. those, 16 showed OAS at least one pear (OAS (+) group), rest cases no (−) group). value significantly higher group ( p = .014), highest area under receiver operating characteristics curve. cut‐off detection 2.65 UA/ml, a sensitivity 62.5% specificity 81.3%. Other values not different two groups. Conclusions In subjects sensitized allergens, fruits.